Functionalized Porous Silica Microspheres as Scavengers in Parallel Synthesis

Authors: Thompson L.A.; Combs A.P.; Trainor G.L.; Wang Q.; Langlois T.J.; Kirkland J.J.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 2, April 2000 , pp. 107-115(9)

Publisher: Bentham Science Publishers

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Abstract:

The use of solid scavengers in parallel solution-phase organic synthesis is an effective method for work-up and purification. Functionalized macroreticular or gel-form polystyrene particles are generally used for scavenging applications, how ever these materials have some limitations. We have developed new scavenging reagents based on ultrapure silica microspheres displaying a variety of functional groups useful for sequestering impurities from reaction products. These materials are easy to handle, have excellent mass-transfer properties, and are efficient scavengers in both polar and nonpolar organic solvents. The properties of these materials were tailored specifically to fit the needs of a medicinal chemist employing parallel synthesis techniques in current commercial equipment. Results are presented from head-to-head comparisons with conventional scavengers in tests designed to demonstrate the versatility of these new materials.

Keywords: Porus silica micropheres; Scavengers; Parallel synthesis; Calypso; Synthesis

Language: English

Document Type: Regular paper

DOI: 10.2174/1386207003331670

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