Polymer-Supported Reagents and Catalysts Recent Advances in Synthetic Applications

Author: Bhattacharyya S.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 2, April 2000 , pp.

Publisher: Bentham Science Publishers

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Abstract:

The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.

Keywords: Polymer supported reagents; Catalysts; Synthetic application; Solution phase organic reaction; Polymer bound reagents; Mitsunobu reaction; Horner emmons reaction; Polymer bound atalysts; Nafion membrane catalysis; Resin bound cobalt II catalyst

Language: English

Document Type: Review article

DOI: 10.2174/1386207003331751

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