Polymer-Supported Reagents and Catalysts Recent Advances in Synthetic Applications

Author: Bhattacharyya S.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 3, Number 2, April 2000

Publisher: Bentham Science Publishers

Abstract:

The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.

Keywords: Polymer supported reagents; Catalysts; Synthetic application; Solution phase organic reaction; Polymer bound reagents; Mitsunobu reaction; Horner emmons reaction; Polymer bound atalysts; Nafion membrane catalysis; Resin bound cobalt II catalyst

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1386207003331751

Publication date: 2000-04-01

• Combinatorial Chemistry & High Throughput Screening publishes full length original research articles and reviews describing various topics in combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) and/or high throughput screening (e.g. developmental, practical or theoretical). Ancillary subjects of key importance, such as robotics and informatics, will also be covered by the journal. In these respective subject areas, Combinatorial Chemistry & High Throughput Screening is intended to function as the most comprehensive and up-to-date medium available. The journal should be of value to individuals engaged in the process of drug discoveryand development, in the settings of industry, academia or government.

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