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Magnetic Iron Oxide Nanoparticles for Tumor-Targeted Therapy

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Abstract:

Magnetic nanoparticles have been intensively investigated due to their magnetic characteristics, quantum dot effects, as well as their potential applications in the area of bioscience and medicine. Very promising nanoparticles are magnetic iron oxide nanoparticles with appropriate surface modification which have been widely used experimentally for masses of in vivo applications such as magnetic resonance imaging contrast enhancement, drug delivery, and hyperthermia, etc.. All these biomedical applications require that these nanoparticles have effective magnetic values and suitable sizes. On the other hand, these applications need special surface modification of these particles, which not only have to be non-toxic and biocompatible, but also allow a targetable drug delivery in a specific area. This review summarizes the current research situation and development of magnetic iron oxide nanoparticles, and the biomedical applications ranging from drug delivery to hyperthermia for tumor-targeted therapy.





Keywords: 5-Fluorouracil; Hyperthermia; Magnetic nanoparticle; Nanotechnology; O-carboxymethylchitosan; adriamycin; camptothecin; drug delivery; glioblastoma cells; hyperthermia; iron oxide; magnetic drug targeting (MDT); magnetic hyperthermia; magnetic resonance; malignancies; nanoimmunoliposome; phagolysis; prostate cancer; reticuloendothe-lial system; surface modification; targeted therapy; tumor necrosis factor

Document Type: Research Article

Publication date: February 1, 2011

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  • Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes, genes.
    Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cancer.
    As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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