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Silica Nanoparticles as Promising Drug/Gene Delivery Carriers and Fluorescent Nano-Probes: Recent Advances

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The application of nanotechnology to biomedical research is expected to have a major impact leading to the development of new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is to develop safe and efficient drug/gene delivery vehicles. Research into the rational delivery and targeting of pharmaceutical, therapeutic and diagnostic agents is at the forefront of projects in nanomedicine. Silica, as a major and natural component of sand and glass, is a versatile material due to the variety of available chemical and physical modifications that are available, and recently have been widely applied in nanobiotechnology as drug/gene carriers or fluorescent nano-probes. The goal of this brief review is to illustrate selected examples of various functionalized silica nanoparticles as drug/gene delivery systems that have been applied to the arenas of human disease therapy or detection (molecular and cellular imaging).

Keywords: 2-devinyl-2-(1-hexyloxyethyl) pyropheo-phorbide; DNA microarray; Folic acid; Silica; adenocarcinoma; antisense oligonucleotides; apoptosis; bromodeoxyuridine; cytoskeleton; drug/gene delivery; electrostatic interaction; fluorescein isothiocyanate; fluorescent dye; glutaraldehyde; immu-nocytochemistry; immunohistochemistry; immunosorbent assay; liposomes; luminescent; mesenchymal stem cells; mesoporous channels; mesoporous silica nanoparticles; nano-probes; nanobiotechnology; nanoparticles; nanotechnology; perfluorocarbon; photodynamic drugs; pituitary adenoma; plasmid DNA; polyethylene glycol; proliferation; sodium cyanide; sol-gel; stereotaxic injections; superparamagnetic iron ox-ide; superparamagnetic iron oxide; targeting; tetraethoxysilane; thiol-organosilica

Document Type: Research Article

Publication date: February 1, 2011

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