Examining the Relationship between Cancer Invasion / Metastasis and Drug Resistance

Authors: Liang Y.; McDonnell S.; Clynes M.

Source: Current Cancer Drug Targets, Volume 2, Number 3, September 2002 , pp. 257-277(21)

Publisher: Bentham Science Publishers

Abstract:

Studies of cancer invasion / metastasis and drug resistance have in the past generally proceeded along the separate pathways of research. Recently, however, interest has been focused on the possible relationship between drug resistance and cancer invasion and metastasis. A relationship between these two phenotypes has been demonstrated by two types of observation: firstly, some tumor cells selected for resistance to drugs are more invasive / metastatic relative to non-resistant parental cells, secondly, in some cases, secondary (more metastatic) tumors are more resistant to chemotherapeutic drugs than their primary counterparts. In other instances reported in the literature, no correlation is seen between drug exposure / resistance and cancer invasion / metastasis. The possibility that treatment with some chemotherapeutic drugs may be able to promote cancer invasion and metastasis needs further investigation because of its potential clinical relevance. A better understanding of any relationship between drug resistance and cancer invasion could lead to more effective cancer treatment.

Keywords: cancer invasion; drug resistance; phenotypes; effective cancer treatment; circulatory anatomy; metastatic tumors; cytokeratins and vimentin

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1568009023333872

Publication date: 2002-09-01

• Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes, genes.
  Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cancer.
  As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

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• In this Subject: Oncology ,  Pharmacology
• By this author: Liang Y. ;  McDonnell S. ;  Clynes M.

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