Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes

Author: Walker M.G.

Source: Current Cancer Drug Targets, Volume 1, Number 1, May 2001 , pp. 73-83(11)

Publisher: Bentham Science Publishers

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Abstract:

Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drug's mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.

Keywords: Gene Expression Analysis; hepatitis B viral protein; Fisher Exact test; Bonferroni; papillomavirus; hypothetical genes

Language: English

Document Type: Review article

DOI: 10.2174/1568009013334241

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