Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes

Author: Walker M.G.

Source: Current Cancer Drug Targets, Volume 1, Number 1, May 2001 , pp. 73-83(11)

Publisher: Bentham Science Publishers

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Abstract:

Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drug's mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.

Keywords: Gene Expression Analysis; hepatitis B viral protein; Fisher Exact test; Bonferroni; papillomavirus; hypothetical genes

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1568009013334241

Publication date: 2001-05-01

More about this publication?

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes, genes.
Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cancer.
As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.