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Bioinformatics Studies on Induced Pluripotent Stem Cell

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The induced pluripotent stem cells (iPSCs), generated from transcription factor-induced reprogramming, hold the great promise as the next generation materials for regenerative medicine. Intensive follow-up studies have accumulated a large amount of high-throughput data in transcription, proteomics, methylation, and other levels, which makes the computational studies feasible. Here we briefly review the recent bioinformatics efforts to study iPSCs. Specifically, we will summarize several comparison studies to determine how closely human iPSCs resemble human embryonic stem cells (ESCs) from sequence, gene expression profile, chromatin structure, DNA methylation, proteomics, and function aspects. Then computational methods to assess iPSC's pluripotency in a cost-effective yet accurate way are introduced. Finally, we will indicate the further biomolecular network studies to understand the underlying mechanism for cell reprogramming and the dynamics within this biological process.
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Keywords: Cell reprogramming; DNA methylation; Forward Engineering Strategy; chromatin structure; dynamics; gene expression profile; gene regulatory network; induced pluripotent stem cells; proteomics; sequence; transcriptional similarity

Document Type: Research Article

Publication date: 2013-02-01

More about this publication?
  • Current Bioinformatics aims to publish all the latest and outstanding developments in bioinformatics. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a wide range of the integration of biology with computer and information science.

    The journal focuses on reviews on advances in computational molecular/structural biology, encompassing areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.

    Current Bioinformatics is an essential journal for all academic and industrial researchers who want expert knowledge on all major advances in bioinformatics.
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