IMGT®, the international ImMunoGeneTics information system® (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system (RPI) of any species. RPI include proteins that belong to the immunoglobulin superfamily (IgSF) and MHC superfamily (MhcSF). IMGT has set up a unique numbering system, which takes into account the structural features of the Ig-like and Mhc-like domains. In this paper, we describe the IMGT Scientific chart rules for the description of the IgSF V type and C type and of the MhcSF G type domains. These rules are based on the IMGT-ONTOLOGY concepts and are applicable for the sequence and structure analysis, whatever the species, the IgSF or MhcSF protein, or the chain type. We present examples of IMGT Colliers de Perles of IgSF V type (V-DOMAIN and V-LIKE-DOMAIN), C type (C-DOMAIN and C-LIKE-DOMAIN) and MhcSF G type (G-DOMAIN and G-LIKE-DOMAIN) based on the IMGT unique numbering. These standardized two-dimensional graphical representations are particularly useful for antibody engineering, sequence- structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis.
No Supplementary Data
No Article Media
major histocompatibility complex superfamily
Document Type: Research Article
International ImMunoGeneTics Information System® (IMGT®), Laboratoire d'ImmunoGenetique Moleculaire, LIGM, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France.
Publication date: 2007-01-01
More about this publication?
Current Bioinformatics aims to publish all the latest and outstanding developments in bioinformatics. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a wide range of the integration of biology with computer and information science.
The journal focuses on reviews on advances in computational molecular/structural biology, encompassing areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.
Current Bioinformatics is an essential journal for all academic and industrial researchers who want expert knowledge on all major advances in bioinformatics.