Bioinformatic Application in Proteomic Research on Biomarker Discovery and Drug Target Validation

Authors: Wang, Ying; Chiu, Jen-Fu; He, Qing-Yu

Source: Current Bioinformatics, Volume 2, Number 1, January 2007 , pp. 11-20(10)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $62.88 plus tax (Refund Policy)

Abstract:

Novel biomarker identification and drug target validation are highly complex and resource-intensive processes, requiring an integral use of various tools, approaches and information. The recently developed proteomic technology features high-throughput parallel analysis of thousands of proteins in individual patients and amount populations and thus opens up the possibility of providing more details at a global level on the molecular mechanisms. With regularly updated public databases, bioinformatics can contribute to these processes by providing functional information of target candidates and correlating this information to the biological pathways. In this review, we outline recent advances of bioinformatic application in proteomic research on biomarker discovery and drug target validation. Specifically, we highlight how bioinformatics can facilitate the proteomic studies of biomarker identification and drug target validation.

Keywords: Bioinformatics; biomarker discovery; drug design; drug development; proteomics

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157489307779314294

Affiliations: 1: Department of Chemistry,The University of Hong Kong, Pokfulam, Hong Kong, China.

Publication date: 2007-01-01

More about this publication?

Current Bioinformatics aims to publish all the latest and outstanding developments in bioinformatics. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a wide range of the integration of biology with computer and information science.

The journal focuses on reviews on advances in computational molecular/structural biology, encompassing areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.

Current Bioinformatics is an essential journal for all academic and industrial researchers who want expert knowledge on all major advances in bioinformatics.

Bioinformatic Application in Proteomic Research on Biomarker Discovery and Drug Target Validation

Buy & download fulltext article:

Tools

Key

Text size:

Useful pages