Authors: Sebahar, Paul R.; Willardsen, J. A.; Anderson, Mark B.

Source: Current Bioactive Compounds, Volume 5, Number 1, March 2009 , pp. 79-97(19)

Publisher: Bentham Science Publishers

Abstract:

The tumor vasculature is quite an attractive target for anti-cancer/anti-tumor therapy because the blood vessels provide the route for nutrient/waste and oxygen/carbon dioxide exchanges as well as a convenient route for tumor metastatic spread. The complex interplay of the tumor with the local blood vasculature is intriguing. Targeting the vasculature in an effort to control the tumor life cycle is therefore very complex yet enticing as a treatment option. In reviewing the literature discussing vascular targeting/disrupting agents, it is sometimes less than clear as to what exactly defines or differentiates a vascular targeting agent (VTA; antiangiogenic or stopping tumors from producing new blood vessels) from a vascular disrupting agent (VDA; disrupting the "established" tumor vasculature). Although, there appears to be differences between these two strategies of modifying the tumor vasculature including differences in the administration schedules. The use of the VTA/VDA terms in scientific reports is not always clear since some agents may also exhibit activities attributed to a VTA and/or a VDA. However these agents are defined, the important goal is to severely cripple and/or “shut-down” the tumor's ability to maintain viability and to subsequently become metastatic and hence are important in the armamentarium of anti-tumor/anti-cancer treatment strategies. This brief review of selected literature reports attempts to summarize some of the chemical structural elements associated with these types of agents and asks the question “Are there common chemical structural features emerging that may assist in a differentiating theme?”

Keywords: Vascular disrupting; vascular targeting; tubulin; oncology; angiogenesis; inhibitor

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157340709787580919

Publication date: 2009-03-01

More about this publication?

• The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.
  
  The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.

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