Authors: Zito, S. W.; Shinde, J.; Chen, I-C. S.; Taldone, T.; Barletta, M.

Source: Current Bioactive Compounds, Volume 4, Number 2, August 2008 , pp. 68-85(18)

Publisher: Bentham Science Publishers

Abstract:

In this review, we focus on the chemicals used in the current treatment of type 2 diabetes and discuss some potentially viable, promising targets in the management of this metabolic syndrome, with a special mention to some naturally occurring bioactive compounds. Non-insulin dependent diabetes mellitus (NIDDM or Type 2 diabetes) is a prevalent, chronic metabolic disorder, which affects more than 171 million people worldwide. Diminished insulin secretion due to impaired β-cell function and/or insulin resistance of the peripheral tissues such as liver, adipose tissue and skeletal muscle causes hyperglycemia, which is controlled with suitable pharmacological agents. The current line of treatment includes: (1) insulin secretagogues, (2) insulin sensitizers, (3) dipeptidyl peptidase-IV inhibitors, (4) biguanides, (5) α-glucosidase inhibitors and (6) drugs in development.

Keywords: Oral Hypoglycemics; metabolic syndromeNon-insulin dependent diabetes m; chronic metabolic disorder; hyperglycemia; insulin sensitizers; biguanides

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157340708785294190

Publication date: 2008-08-01

More about this publication?

• The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.
  
  The journal should prove to be essential reading for pharmacologists, pharmaceutical chemists and medicinal chemists who wish to be kept informed and up-to-date with the latest and most important developments about new bioactive compounds of natural or synthetic origin, including recent patents.

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