Oral Hypoglycemics: A Review of Chemicals Used to Treat Type 2 Diabetes
Authors: Zito, S. W.; Shinde, J.; Chen, I-C. S.; Taldone, T.; Barletta, M.
Source: Current Bioactive Compounds, Volume 4, Number 2, August 2008 , pp. 68-85(18)
Publisher: Bentham Science Publishers
Abstract:
In this review, we focus on the chemicals used in the current treatment of type 2 diabetes and discuss some potentially viable, promising targets in the management of this metabolic syndrome, with a special mention to some naturally occurring bioactive compounds. Non-insulin dependent diabetes mellitus (NIDDM or Type 2 diabetes) is a prevalent, chronic metabolic disorder, which affects more than 171 million people worldwide. Diminished insulin secretion due to impaired β-cell function and/or insulin resistance of the peripheral tissues such as liver, adipose tissue and skeletal muscle causes hyperglycemia, which is controlled with suitable pharmacological agents. The current line of treatment includes: (1) insulin secretagogues, (2) insulin sensitizers, (3) dipeptidyl peptidase-IV inhibitors, (4) biguanides, (5) α-glucosidase inhibitors and (6) drugs in development.Keywords: Oral Hypoglycemics; metabolic syndromeNon-insulin dependent diabetes m; chronic metabolic disorder; hyperglycemia; insulin sensitizers; biguanides
Document Type: Research article
DOI: http://dx.doi.org/10.2174/157340708785294190
Publication date: 2008-08-01
- The journal aims to provide updates to researchers about new bioactive compounds with proven activities in various biological screenings and pharmacological models. The journal will contain information about the structures, biological activities and sources of chemical entities discovered or designed by researchers and published in leading journals. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia.
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- By this author: Zito, S. W. ; Shinde, J. ; Chen, I-C. S. ; Taldone, T. ; Barletta, M.

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