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Polyphenols and Aging

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Age-associated changes within an individual are inherently complex and occur at multiple levels of organismal function. The overall decline in function of various tissues is known to play a key role in both aging and the complex etiology of certain age-associated diseases such as Alzheimer's disease (AD) and cancer. Continuing research highlights the dynamic capacity of polyphenols to protect against age-associated disorders through a variety of important mechanisms. Numerous lines of evidence suggest that dietary polyphenols such as resveratrol, (-)-epigallocatechin-3-gallate (EGCG), and curcumin have the capacity to mitigate age-associated cellular damage induced via metabolic production of reactive oxygen species (ROS). However, recently acquired evidence also demonstrates a likely role for these polyphenols as anticancer agents capable of preventing formation of new vasculature in neoplastic tissues. Polyphenols have also been shown to possess other anticancer properties such as specific cell-signaling actions that may stimulate the activity of the regulatory protein SIRT1. Additionally, polyphenolic compounds have demonstrated their inhibitory effects against chronic vascular inflammation associated with atherosclerosis. These increasingly well-documented results have begun to provide a basis for considering the use of polyphenols in the development of novel therapies for certain human diseases. And while the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for polyphenols as pharmacological interventions against specific age-associated diseases.





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Keywords: Alzheimer's disease; Polyphenols; SIRT1; aging; angiogenesis; cancer; neuroprotection

Document Type: Research Article

Publication date: 2010-02-01

More about this publication?
  • Current Aging Science publishes frontier review and experimental articles in all areas of aging and age-related research that may influence longevity. This multidisciplinary journal will help in understanding the biology and mechanism of aging, genetics, pathogenesis, intervention of normal aging process and preventive strategies of age-related disorders. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, clinical, molecular, and animal models, including lower organism models (e.g., yeast, Caenorhabditis elegans and Drosophila). In addition to the affect of aging on integrated systems, the journal also covers original articles on recent research in fast emerging areas of adults stem cells, brain imaging, calorie restriction, immunosenescence, molecular diagnostics, pharmacology and clinical aspects of aging. Manuscripts are encouraged that relate to developmental programming of aging and the synergistic mechanism of aging with cardiovascular diseases, obesity and neurodegenerative disorders.

    Book reviews, meeting reports and letters-to-the-editor and drug clinical trial studies are also published. The journal is essential reading for researchers, educators and physicians with interest in aging, age-related dementia and Alzheimer's disease and longevity. Current Aging Science provides a comprehensive coverage of the current state of aging research for gerontologists, neuroscientists, clinicians, health science planners, granting agencies and pharmaceutical scientists.

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