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Animal Models of Obesity and Metabolic Syndrome: Potential Tools for Alzheimer's Disease Research
Author: Abraham, Kristin M.
Source: Current Alzheimer Research, Volume 4, Number 2, April 2007 , pp. 145-146(2)
Publisher: Bentham Science Publishers
Abstract:
Emerging evidence suggests that components of the metabolic syndrome either in isolation or in aggregate may impact the onset or severity of neurodegenerative processes, including those physiologic changes that lead to Alzheimer's Disease (AD). Several animal models that were originally designed to interrogate the metabolic syndrome are readily available. These models can now be used to support studies that may provide new mechanistic links between the metabolic syndrome and neurodegeneration. In addition, animal strains currently being generated and phenotyped through the efforts of an array of NIDDK-supported projects are likely to provide novel and better tools to advance Alzheimer's disease research in the near future.Keywords: Metabolic Syndrome; Insulin Resistance; Obesity; Alzheimer's Disease; Animal Models
Document Type: Research article
DOI: http://dx.doi.org/10.2174/156720507780362209
Affiliations: 1: Division of Diabetes, Endocrinology and Metabolic Diseases, NIDDK - NIH, 6707 Democracy Blvd Rm 795, Bethesda, MD 20892-5460, USA.
Publication date: 2007-04-01
- Current Alzheimer Research publishes peer-reviewed frontier review and research articles on all areas of Alzheimer's disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer's disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer's disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer's disease. Current Alzheimer Research provides a comprehensive 'bird's-eye view' of the current state of Alzheimer's research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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- In this Subject: Neurology & Psychiatry , Pathology
- By this author: Abraham, Kristin M.
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