New Approaches in Nuclear Medicine for Early Diagnosis of Alzheimer's Disease

Authors: S. Mirzaei; E. Gelpi; J. Booij; M. Rodrigues; I. Neumann; J. Zaknun; H. Koehn; P. Knoll

Source: Current Alzheimer Research, Volume 1, Number 3, August 2004 , pp. 219-229(11)

Publisher: Bentham Science Publishers

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Abstract:

Dementia, Alzheimer's disease (AD) being the most common cause of it, is a major and growing medical and social problem, particularly in the advanced age, with the highest rate in the population over 75 y. Recent sophisticated therapeutic measures require more sensitive diagnostic tests to recognize early stages of the disease. In this paper, the current neuronuclear imaging literature is reviewed with regard to early and differential diagnosis of dementia. Functional imaging with single photon emission computed tomography (SPECT) and positron emission tomography (PET) could provide the clinician with additional information complementary to morphological assessments, thus contributing to achieve a more adequate diagnosis, and also with information regarding prodromal stages of AD.

Keywords: dementia; alzheimer disease; pet; spect

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1567205043332135

Affiliations: 1: Centre Hospitalier de Luxembourg, Service de Medecine Nucleaire 4, rue Barble, L-1210 Luxembourg.

Publication date: 2004-08-01

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Current Alzheimer Research publishes peer-reviewed frontier review and research articles on all areas of Alzheimer's disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer's disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer's disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer's disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer's disease. Current Alzheimer Research provides a comprehensive 'bird's-eye view' of the current state of Alzheimer's research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.

New Approaches in Nuclear Medicine for Early Diagnosis of Alzheimer's Disease

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