Molecular Dynamics Simulations of Intrinsically Disordered Proteins in Human Diseases

Authors: Wang, Jihua; Cao, Zanxia; Li, Shuqiang

Source: Current Computer - Aided Drug Design, Volume 5, Number 4, December 2009 , pp. 280-287(8)

Publisher: Bentham Science Publishers

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Abstract:

Recent structural and genomic studies have clearly shown that many proteins contain long regions that do not adopt any globular structures under native conditions. These regions are termed intrinsically disordered or unstructured, and the proteins with intrinsically disordered regions are called intrinsically disordered proteins (IDPs). Current studies estimate that one third of eukaryotic proteins contain stretches of at least 30 contiguous disordered residues, the predictions are even higher in cancer-associated and signaling proteins (80% and 67%, respectively). IDPs play crucial roles in many aspects of molecular and cell biology and numerous IDPs are associated with human diseases such as cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases, diabetes and others. IDPs such as tumor suppressor P53, BRCA1, Parkinson's protein α-synuclein, Alzheimer disease protein tau and many other diseaseassociated hub proteins represent attractive targets for drugs modulating protein-protein interactions. The structures and dynamics of the disordered proteins are the basis for the novel drug discovery. IDPs are lack of stable tertiary and /or secondary structure under physiological conditions in vitro. It is difficult to obtain accurate experimental measurements for the structures and dynamics of the disordered proteins. Molecular dynamics simulations provide available powerful tools to calculate the structures and their related dynamics of IDPs. In this paper, we focus on structural and dynamics insights of disease-associated disordered proteins by molecular dynamics simulations.

Keywords: Intrinsically disordered proteins; molecular dynamics simulations; P53; α-synuclein; drug discovery

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157340909789577865

Publication date: 2009-12-01

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Current Computer-Aided Drug Design aims to publish all the latest developments in drug design based on computational techniques. The field of computer-aided drug design has had extensive impact in the area of drug design. Current Computer-Aided Drug Design is an essential journal for all medicinal chemists who wish to be kept informed and up-to-date with all the latest and important developments in computer-aided methodologies and their applications in drug discovery. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of computational techniques for drug design, screening, ADME studies, etc., providing excellent rationales for drug development.

Molecular Dynamics Simulations of Intrinsically Disordered Proteins in Human Diseases

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