Authors: Sobolev, Boris N.; Olenina, Ludmila V.; Kolesanova, Ekaterina F.; Poroikov, Vladimir V.; Archakov, Alexander I.

Source: Current Computer - Aided Drug Design, Volume 1, Number 2, April 2005 , pp. 207-222(16)

Publisher: Bentham Science Publishers

Abstract:

Development of computer methods in molecular biology and fast growth of microbial genomics data enabled new approach based on selecting in silico antigenic components to design vaccine constructs. It is expected that application of this technology will eliminate side effects of new vaccines and reduce the time consumption and financial expenses. The bioinformatics methods of sequence analysis are used to reveal the most prospective proteins or protein fragments of infectious agents as candidates for vaccine design. In these studies the specialized molecular immunology databases are widely used. The new approach (“Reverse vaccinology”) could help in designing vaccines against diseases where traditional methods are not successful, e.g. when the viral genome reveals the extreme variability and permanent changes of antigenic properties that make difficulties for selection of molecular targets for medicines and candidate vaccines. A number of informational resources are already designed to collect and provide genomic data on certain microbes or viruses. The peculiarity of such resources is presentation of data, characterizing the different genomic variants of the same infectious agents. These structural data coupled with information on functional / immune features and software tools have to compose basis for constructing a new generation of vaccines against “common” and new infections such as AIDS, Hepatitis C, and SARS. The approaches published in literature, as well as the authors' original results are discussed.

Keywords: vaccine design; immune response; genomics; bioinformatics; immunoinformatics; sequence analysis; epitope prediction; informational resources

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1573409053585681

Affiliations: 1: Institute of Biomedical Chemistry of Rus. Acad. Med. Sci., Pogodinskaya Street, 10; Moscow, 119121, Russia.

Publication date: 2005-04-01

More about this publication?

• Current Computer-Aided Drug Design aims to publish all the latest developments in drug design based on computational techniques. The field of computer-aided drug design has had extensive impact in the area of drug design. Current Computer-Aided Drug Design is an essential journal for all medicinal chemists who wish to be kept informed and up-to-date with all the latest and important developments in computer-aided methodologies and their applications in drug discovery. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of computational techniques for drug design, screening, ADME studies, etc., providing excellent rationales for drug development.

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