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Molecularly Imprinted Polymers as Selective Recognition Elements in Optical Sensing

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Molecular imprinted polymers (MIPs) are molecular recognition elements that can be tailored towards a wide variety of target molecules. These human-made materials are relatively easy to prepare and have found a broad application as substitutes of antibodies or enzymes. They have been successfully applied to the development of chromatographic or solid phase extraction methods and have attracted a great interest for the development of electrochemical, piezoelectrical or optical sensors. In parallel with the classification of biosensors, MIP-based devices can work according to two different detection schemes: affinity sensors (“plastic-bodies”) and catalytic sensors (“plastic-enzymes”). These devices can be interrogated using different optical techniques, such as fluorescence, light absorption (UV-Vis, Infrared) spectroscopy, chemiluminescence, surface plasmon resonance, or Raman scattering. This paper reviews the main developments and applications of MIPs in the area of optical sensors with special emphasis on their analytical applications.

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Keywords: Absorbance; Biomimetic receptors; Fluorescence; Molecularly imprinted polymers (MIPs); Optical sensors; Surface plasmon resonance

Document Type: Research Article

Publication date: 2008-10-01

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  • Current Analytical Chemistry publishes authoritative reviews, written by experts in the field on all the most recent advances in analytical chemistry. All aspects of the field are represented including analytical methodology, techniques and instrumentation in both fundamental and applied areas of the field. The journal is essential to all involved in analytical chemistry and applied areas.
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