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Does Inhaled Corticosteroid Treatment Result in a Secondary Immune Deficiency Predisposing To Recurrent Infections?

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Abstract:

It is well known that long-term treatment with systemic steroids exerts immune-suppressive effects on the cellular immune system and increase the susceptibility to all types of intracellular infections. Inhaled corticosteroids have been the mainstay treatment for asthma for a long period and are generally accepted as safe with no or minimal systemic absorption. Although, these medications are usually used for long periods and sometimes in high doses, there is scarce evidence on their impact on cell mediated immunity, reactivation of tuberculosis in tuberculin skin test positive patients, innate and anti-viral immunity. Hereby, the studies on immune-suppressive effects of inhaled steroids are discussed focusing on cell mediated and antiviral immunity.

Keywords: Human; immune deficiency; immune system; infection; inhaled corticosteroids; side effects

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187152312804142812

Publication date: December 1, 2012

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  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Anti-Inflammatory & Anti-Allergy Agents.

    Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Anti-Inflammatory & Anti-Allergy Medicinal Chemistry.

    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Anti-Inflammatory & Anti-Allergy Agents drug discovery.
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