@article {Tahir:September 2008:1871-5230:231, author = "Tahir, Syed", author = "Nappi, Anthony", author = "Kapur, Navin K.", title = "Atherosclerosis and Inflammation: Insight from Carotid and Intracoronary Ultrasound Studies", journal = "Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Cu rrent Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)", volume = "7", year = "September 2008", abstract = "Dating back to the early 1900's, clinical observations have pointed towards an intimate relationship between dyslipidemia, inflammation, and endothelial dysfunction in the pathogenesis of atherosclerosis. Despite a focus on aggressive lowering of low-density lipoprotein cholesterol (LDL-C) in patients at risk for developing cardiovascular disease, only moderate reductions in cardiovascular events have been achieved, suggesting other targets of therapy should be investigated. Over the past two decades pre-clinical and clinical data have demonstrated a direct correlation between inflammation and atheroma development. This review provides a detailed understanding of inflammation in atherogenesis with a particular emphasis on clinical studies correlating markers of inflammation with plaque progression using carotid intima-media thickness measurements and intravascular ultrasound.
", pages = "231-238(8)", url = "http://www.ingentaconnect.com/content/ben/aiaamc/2008/00000007/00000003/art00011" doi = "doi:10.2174/187152308785699227" }