Authors: Tahir, Syed; Nappi, Anthony; Kapur, Navin K.

Source: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Cu, Volume 7, Number 3, September 2008 , pp. 231-238(8)

Publisher: Bentham Science Publishers

Abstract:

Dating back to the early 1900's, clinical observations have pointed towards an intimate relationship between dyslipidemia, inflammation, and endothelial dysfunction in the pathogenesis of atherosclerosis. Despite a focus on aggressive lowering of low-density lipoprotein cholesterol (LDL-C) in patients at risk for developing cardiovascular disease, only moderate reductions in cardiovascular events have been achieved, suggesting other targets of therapy should be investigated. Over the past two decades pre-clinical and clinical data have demonstrated a direct correlation between inflammation and atheroma development. This review provides a detailed understanding of inflammation in atherogenesis with a particular emphasis on clinical studies correlating markers of inflammation with plaque progression using carotid intima-media thickness measurements and intravascular ultrasound.

Keywords: Atherosclerosis; inflammation; atherogenesis; soluble markers; intravascular ultrasound; carotid intima-media thickness

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187152308785699227

Publication date: 2008-09-01

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