Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2

Authors: Magrioti, Victoria; Kokotos, George

Source: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Cu, Volume 5, Number 2, May 2006 , pp. 189-203(15)

Publisher: Bentham Science Publishers

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Abstract:

PLA2 is an important signaling enzyme that generates multiple downstream effectors, such as arachidonic acid and PAF, which are key mediators of inflammation as well as other pathophysiological conditions. Inhibition of PLA2 is potentially an effective therapy for several inflammatory diseases. In this review, we discuss the various classes of synthetic inhibitors of Group IVA and Group VIA phospholipase A2.

Keywords: Analgesic; anti-inflammatory agents; inflammation; inhibitors; 2-oxoamide; pain; phospholipase A2; trifluoromethyl ketone

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187152306776872451

Affiliations: 1: Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, 15771 Athens, Greece.

Publication date: 2006-05-01

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