Skip to main content

Vascular Reactions of Iodinated X-Ray Contrast Media: Mechanisms and Possible Therapeutic Interventions

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

Vascular reactions after administration of all classes of iodinated x-ray contrast media are well known side effects of these drugs. Both vasodilation and vasoconstriction have been observed. The manner and extent of the change in vessel tone depends on the type of contrast medium, species, vascular territory and contractile state of the vessels. The mechanisms underlying the vascular reaction induced by contrast media are currently not completely clear and studies on this question are partly contradictory or non-conclusive. Even if these side effects do not vitally compromise the patients, they are mainly responsible for patients' discomfort during examinations. To date, there are only a few possibilities to treat this type of side effect.

In this review we describe the effects of high osmolar ionic, low osmolar non-ionic and isotonic contrast media on different vascular beds in humans and animals. Data from clinical and in vivo studies as well as from in vitro investigations on isolated organs and isolated vessel segments will be discussed. It will give an overview of the mechanistic explanations of the vascular reactions.



Keywords: Contrast media; coronary circulation; endothelium; pulmonary circulation; renal circulation; vascular smooth muscle; vasoconstriction; vasodilation

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187152306776872497

Affiliations: Department of diagnostic Radiology, University Hospital, Maximiliansplatz 1, 91054 Erlangen, Germany.

Publication date: May 1, 2006

More about this publication?
  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Anti-Inflammatory & Anti-Allergy Agents.

    Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Anti-Inflammatory & Anti-Allergy Medicinal Chemistry.

    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Anti-Inflammatory & Anti-Allergy Agents drug discovery.
ben/aiaamc/2006/00000005/00000002/art00005
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more