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Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives

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Abstract:

A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.

Keywords: 1; 4-benzodiazepines; Anti-inflammatory; Anticancer activity; Myeloperoxidase

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/187152012800617713

Affiliations: Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Circuito Exterior, Coyoacan, C.P. 04510, Mexico D.F., Mexico.

Publication date: July 1, 2012

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