Skip to main content

Sensitive Determination of Dopamine by Its Fluorescence Enhancement on Terbium(III)-Dipicolinic Acid System

Buy Article:

$105.00 plus tax (Refund Policy)

Biologically important compound dopamine plays an important role in the central and peripheral nervous systems. Insufficient dopamine level due to the loss of dopamine cells may lead to disease called schizophrenia and Parkinson's disease. An enhanced fluorimetric determination of dopamine is achieved using fluorescence of terbium complex, Tb3+–DPA, where DPA is dipicolinic acid. Under the optimum conditions, the method showed good stability and reproducibility. The application of this method for the determination of dopamine was found to be satisfactory. Linear response was found in the range of 5 × 10−8 M–2 × 10−6 M with a detection limit of 1.2 × 10−8 M. Recovery of the target compounds was obtained more than 98% with good quality parameters: linearity (r 2 > 0.997), limit of detection (LOD) and limit of quantification (LOQ) values 1.2 × 10−8 M and 4.1 × 10−8 M, respectively, and run-to-run and day-to-day precisions (from 10 independent measurements for 1.0 × 10−6 M of dopamine) with relative standard deviation (RSD) 3.33%. The content of the analyzed samples was found 198.4 mg which are very close to the label claimed by the manufacturer (200 mg) in dopaminum hydrochloricum tablets. To the best of our knowledge, such kind of work has been carried out for the first time which offers very good results. Therefore, this method can be proposed for routine analysis of these compounds in tablets.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: 01 January 2012

More about this publication?
  • The growing interest and activity in the field of sensor technologies requires a forum for rapid dissemination of important results: Sensor Letters is that forum. Sensor Letters offers scientists, engineers and medical experts timely, peer-reviewed research on sensor science and technology of the highest quality. Sensor Letters publish original rapid communications, full papers and timely state-of-the-art reviews encompassing the fundamental and applied research on sensor science and technology in all fields of science, engineering, and medicine. Highest priority will be given to short communications reporting important new scientific and technological findings.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more