Determination of Salbutamol Sulfate Based on Chitosan Multi-Wall Carbon Nanotubes Film Modified Glassy Carbon Electrode

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Abstract:

An electrochemical glassy carbon electrode (GCE) modified with a composite film of carboxylated multi-walled carbon nanotubes (MWNTs) and chitosan has been constructed in this paper. It shows excellent electro-catalytic activity toward the electrochemical oxidation of salbutamol sulfate in phosphate buffer. The oxidation peak currents of the electrode are linearly correlated to the concentration of salbutamol sulfate in the range of 0.50–40 μmol/L with a detection limit of 0.086 μmol/L. The electrode possesses a nice recovery of 96.71–106.4% with good reproducibility, stability, selectivity and long lifetime for salbutamol sulfate aerosol samples in comparison with spectrophotometric method, indicating that it is a feasible method for rapid determination of pharmaceutical samples containing salbutamol sulfate.

Keywords: CARBOXYLATED; CHITOSAN; MULTI-WALLED CARBON NANOTUBES; PHARMACEUTICAL ANALYSIS; SALBUTAMOL SULFATE

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/sl.2011.1549

Publication date: October 1, 2011

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