Enzyme Biosensor Based on Hemoglobin Entrapped in Intestine-Like SnO2 Nanostructure

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A new morphology of SnO2, intestine-like nano-cluster was employed for the fabrication of hydrogen peroxide biosensor. The prepared SnO2 exhibited excellent biocompatibility and adsorption of hemoglobin, and the biosensor constructed by electro-codepositing of SnO2 and hemoglobin on gold electrode exhibited sensitive response to the reduction of hydrogen peroxide, and the linear range was from 1 × 10–5 mol L–1 to 1.6 × 10–2 mol L–1 with coefficient constant of 0.99 (n = 23), and the detect limit was estimated to be 3.5 × 10–6 mol L–1 (S/N = 3). The selectivity, reproducibility and stability were also good.


Document Type: Research Article

DOI: http://dx.doi.org/10.1166/sl.2011.1711

Publication date: October 1, 2011

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