A new miniaturized all-solid-state polyvinyl chloride (PVC) membrane Li+-selective electrode with extra ten-fold improved Li-selectivity towards Na + has been described. The selectivity of the membrane contained 6,6-dibenzyl-1,4,8-11-tetraoxosiclotetradecane was improved
with the addition of Trioctylphosphine oxide (TOPO). The effect of TOPO ratio in the electrode membrane was examined under steady-state conditions. The electrode containing TOPO at the ratio of 1.0% performed best potentiometric properties for the serum Li+ assays. The proposed
TOPO-embedded Li+-selective electrodes with improved selectivity (lithium to sodium; 1:1000) had a wide concentration range of 2.7 × 10–6 –1.0 × 10–1 M and a slope of 47.6 mV/decade (R2 = 0.9981). The developed
electrode was analytically applied for the determination of lithium contents of diluted human serum samples by using direct and standard addition measurement methods. The obtained potentiometric results for the serum samples with the proposed electrode were confirmed by atomic absorption spectrophotometry
(AAS) results at 95% confidence level.
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