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Electrochemical Methods of Carbamazepine Determination

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Abstract:

Glassy carbon (GCE), screen-printed carbon (SPCE) and silver nanoparticle-modified carbon screen-printed (AgNPs/SPCE) electrodes are assessed in the determination of carbamazepine (CBZ) using the oxidation signal obtained from differential-pulse adsorptive stripping voltammetry (DPAdSV). Amperometric analysis of CBZ was also performed using an electrochemical biosensor based on the immobilization of the enzyme horseradish peroxidase (HRP) on a SPCE. The best detection limit (0.938 ± 0.006 M) was obtained by using the AgNPs/SPCE. But the best selectivity was obtained with the HRP based electrode. The AgNPs/SPCE and the HRP-based SPCE developed in this work were successfully applied to CBZ determination in pharmaceutical preparations. Interferences of other antiepileptic pharmaceuticals as Phenitoin and Phenobarbital on CBZ measurement were also studied.

Keywords: ADSORPTIVE STRIPPING VOLTAMMETRY; CARBAMAZEPINE; ENZYMATIC BIOSENSOR; HORSERADISH PEROXIDASE; SCREEN-PRINTED ELECTRODES; SILVER NANOPARTICLES

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/sl.2009.1114

Publication date: August 1, 2009

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