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HTS rf SQUID System for Magnetic Nanoparticle Detection

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Abstract:

A gradiometric high temperature superconducting rf SQUID sensor made of Yttrium barium copper oxide is integrated in a microfluidic instrument for readout of magnetic nanoparticle (MNP) assays. Sample handling and freely adjustable distance of sample to sensor is achieved by guiding a capillary through the vacuum along the SQUID. Cooling is realized by means of inserting the SQUID directly into a slit in a sapphire finger. The particles are excited by a transverse magnetic field. The readout can be performed in relaxometric, susceptometric or frequency mixing mode. The system is designed to test different readout schemes and to determine the detection limit of MNP for biological concentration determination assays using the excellent sensitivity of a SQUID.

Keywords: BIOLOGICAL CONCENTRATION DETERMINATION; HTS RF SQUID; MAGNETIC IMMUNOASSAY; MAGNETIC NANOPARTICLES

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/sl.2009.1054

Publication date: June 1, 2009

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