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Label-Free Biosensors for the Detection and Quantification of Cardiovascular Risk Markers

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Abstract:

This paper presents a biosensor implementation for the detection of protein molecules using specific antibodies. Affinity sensors allow the detection and quantification of target molecules in complex mixtures by affinity-based interactions. Immobilized antibody molecules are the probes that bind to specific protein molecules (targets) in biological fluids. In this study, inter-digitated electrodes in the form of capacitance on glass slide were designed, fabricated and used to measure the changes in the dielectric properties of the inter-digitated capacitances. Our results in this study present that with a careful design of micro-interdigitated capacitors, a wider dynamic range and higher sensitivity can be achieved for the detection and quantification of C-Reactive Protein.

Keywords: ANTIBODY; BIOSENSOR; C-REACTIVE PROTEIN; CAPACITIVE; CARDIOVASCULAR

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/sl.2008.521

Publication date: December 1, 2008

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