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pH-Sensitive Thin Films Composed of Poly(methacrylic acid) and Carboxyl-Terminated Dendrimer

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Abstract:

Layer-by-layer (LbL) deposited thin films composed of poly(methacrylic acid) (PMAA) and poly(amide amine) dendrimer (PAMAM) were prepared and pH-induced decomposition was studied using a quartz crystal microbalance (QCM). The PMAA/PAMAM LbL films can be successfully prepared in the acidic solutions through hydrogen bonding and electrostatic interactions as driving forces. The LbL films are decomposed upon exposure to pH 5.5 or more basic solutions due to electrostatic repulsion between the carboxylate anions in PMAA and PAMAM. The usefulness of the thin films as pH-sensitive organic coatings in developing biosensors and drug delivery systems is suggested.

Keywords: BIOSENSOR; CARBOXYL-TERMINATED DENDRIMER; DRUG DELIVERY; PH-SENSITIVE FILMS; POLY(METHACRYLIC ACID)

Document Type: Short Communication

DOI: http://dx.doi.org/10.1166/sl.2008.019

Publication date: February 1, 2008

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