Skip to main content

Detection of C-Reactive Protein Using BioFET and Extended Gate

Buy Article:

$113.00 plus tax (Refund Policy)

Abstract:

A novel immunoassay based on a potentiometric measurement for C-reactive protein (CRP) has been developed using a BioFET and an extended gate. Both the BioFET and the extended gate were fabricated using CMOS process techniques. IdVd (drain voltage versus drain current) characteristics of the BioFET only and the BioFET with the extended gate were measured in PBS (phosphate buffered saline), after SAM (self-assembled monolayer) formation, after anti-CRP immobilization and after CRP antigen–antibody interaction. The relation between a current variation ratio and CRP concentration (3–10 g/ml) was studied. Also, we observed the potential variation with increasing the area of the extended gate. The results show the feasibility of the BioFET and its integration with the extended gate for the detection of CRP. In addition, it is expected that this sensing configuration could be used as a part of lab-on-a-chip for the detection of various other biomarkers.

Keywords: BIOFET; BIOSENSORS; C-REACTIVE PROTEIN; EXTENDED GATE; MYOCARDIAL INFARCTION

Document Type: Research Article

DOI: https://doi.org/10.1166/sl.2007.216

Publication date: 2007-06-01

More about this publication?
  • The growing interest and activity in the field of sensor technologies requires a forum for rapid dissemination of important results: Sensor Letters is that forum. Sensor Letters offers scientists, engineers and medical experts timely, peer-reviewed research on sensor science and technology of the highest quality. Sensor Letters publish original rapid communications, full papers and timely state-of-the-art reviews encompassing the fundamental and applied research on sensor science and technology in all fields of science, engineering, and medicine. Highest priority will be given to short communications reporting important new scientific and technological findings.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more