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An Inhibitor-Type Competitive Analysis Model for Sensors with Small Sensitive Surface Area

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A kinetic model for inhibitor-type competitive analysis of sensor systems with surface-type physical transducers having small-area sensitive surfaces (nano- and microsensors) is considered. We calculated the dependencies of sensor response on concentrations of: (i) low-molecular weight analyte to be determined, (ii) its immobilized analog, and (iii) macromolecular receptor. This allowed us to advance a method for quantitative determination of low-molecular weight analytes in such systems. Our approach uses polydentate molecular receptors whose area of projection onto the transducer surface depends on the number of occupied recognizing sites. Interrelation between the amounts of analyte-macromolecular receptor complexes of different stoichiometries varies depending on the initial concentration of analyte. This results in variation of the limiting surface concentrations of the corresponding interfacial complexes and, consequently, their amount at the physical transducer surface.
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Document Type: Research Article

Publication date: 01 June 2007

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