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Optical Biosensor Analysis in Studying Propyl Gallate Binding to Endothelin-1

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Abstract:

The interaction between propyl gallate (PG) and endothelin-1 (ET-1) was studied by using an optical biosensor. ET-1 was biotinylated and then immobilized onto the biotin surface of the IAsys cuvette via the avidin–biotin system. PG was injected into the cuvette, and the resonant angle shift caused by the binding of PG to the immobilized ET-1 was recorded. The results showed that PG bound ET-1 specifically. ET-1 will provide another target that PG can act on besides thromboxane A2 (TXA2) in vivo. The IAsys biosensor offers an effective way and a new clue to the study of the interaction of PG with the cytokine/receptor system.

Keywords: ENDOTHELIN-1; IASYS BIOSENSOR; INTERACTION; PROPYL GALLATE

Document Type: Research Article

DOI: https://doi.org/10.1166/sl.2005.040

Publication date: 2005-12-01

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