Authors: Takashi Katsu; Hiroki Hirodo

Source: Sensor Letters, Volume 1, Number 1, December 2003 , pp. 99-101(3)

Publisher: American Scientific Publishers

Abstract:

S,S,S-Tris(2-ethylhexyl)phosphorotrithioate proved an effective solvent mediator for constructing a serotonin-selective membrane electrode in combination with an ion exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate. This electrode, in spite of the use of an ion exchanger, had a suppressed response to lipophilic quaternary ammonium ions and a sensitive and selective response to serotonin. In physiological saline containing 150 mM NaCl and 10 mM 4-(2-hydroxyethyl)-2-piperazine-ethanesulfonic acid-NaOH (pH 7.4), the slope and detection limit of the electrode were 53 mV per concentration decade and 40 µM, respectively, and this electrode had the best detection limit of any serotonin-selective electrode developed to date. It exhibited better selectivity for alkali metal cations, including Na⁺, than an electrode made using the corresponding phosphate ester, but suffered a larger degree of interference from quaternary ammonium ions, such as (C₂H₅)₄N⁺ and acetylcholine. However, the interference was much smaller than that for the electrode made using o-nitrophenyl octyl ether, one of the most widely used solvent mediators that responds to organic ammonium ions in order of their lipophilicity.

Keywords: ION-SELECTIVE ELECTRODE; SEROTONIN; S S S-TRIS 2-ETHYLHEXYL PHOSPHOROTRITHIOATE; TRIS 2-ETHYLHEXYL PHOSPHATE; SOLVENT MEDIATOR

Document Type: Research article

DOI: http://dx.doi.org/10.1166/sl.2003.009

Affiliations: 1: Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan

Publication date: 2003-12-01

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