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Silver Nanostar Patterned Substrate for Label-Free Characterization of Breast Cancer Cells based on Surface-Enhanced Raman Spectroscopy

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Characterization of cancer cells is important in case of personalized cancer therapy. Cells can be characterized based on their surface marker expression level using fluorescence or surface-enhanced Raman spectroscopy (SERS) method, but in both cases its needed additional labeling with fluorescent or Raman dyes, those may cause cellular cytotoxicity. In this study, we report silver (Ag) nanostar pattern modified ITO substrate capable of label free characterization of breast cancer cells based on SERS. The substrate was fabricated by depositing homogeneously distributed silver nanostar pattern on ITO-glass surface electrochemically. The substrate was capable to produce highly intense SERS spectra in comparison to gold nanopattern modified substrate. Two different subtypes of breast cancer cells (SK-BR-3 and MCF-7) were immobilized on the substrate separately and successfully distinguished based on the molecular information detected by SERS. Our newly developed substrate can be used as an effective platform for molecular detection and characterization of different cells originated from same or different organs.
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Keywords: BREAST CANCER CELLS; LABEL-FREE CHARACTERIZATION; SERS; SILVER NANOSTAR

Document Type: Research Article

Publication date: 01 November 2014

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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