Effect of Fulvic Acid on Oral Delivery of Carbamazepine
Shilajit has been used in traditional system of medicine since antiquity which is also a rich source of humic substances (Humin, Humic acid and Fulvic acid). These least explored macromolecular humic substances possess several unique properties. Here the Complexation property of Fulvic acid with Carbamazepine is explored for the first time and different in vitro, ex vivo and pharmacodynamic parameters are evaluated. Complexes were evaluated by Differential scanning calorimetry, Fourier transform infra red spectroscopy, X-ray diffraction, solubility analysis, release profile study, computational method and molecular modeling. Optimized complexes were undergone, permeation study across intestine, anticonvulsant activity (Maximal Electro Shock) and biochemical estimations (TBARS and glutathion). These studies confirmed the entrapment efficiency of the fulvic acid. Increased solubility (2268.75%), better release profile (∼81% in 60 min), rat intestinal permeability (>3 times), biochemical and pharmacodynamic studies conferred the best to freeze dried (ratio; 1:2) and kneading (ratio; 1:2) complexes.
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Document Type: Research Article
Publication date: 2011-04-01
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