Effect of Fulvic Acid on Oral Delivery of Carbamazepine

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Abstract:

Shilajit has been used in traditional system of medicine since antiquity which is also a rich source of humic substances (Humin, Humic acid and Fulvic acid). These least explored macromolecular humic substances possess several unique properties. Here the Complexation property of Fulvic acid with Carbamazepine is explored for the first time and different in vitro, ex vivo and pharmacodynamic parameters are evaluated. Complexes were evaluated by Differential scanning calorimetry, Fourier transform infra red spectroscopy, X-ray diffraction, solubility analysis, release profile study, computational method and molecular modeling. Optimized complexes were undergone, permeation study across intestine, anticonvulsant activity (Maximal Electro Shock) and biochemical estimations (TBARS and glutathion). These studies confirmed the entrapment efficiency of the fulvic acid. Increased solubility (2268.75%), better release profile (∼81% in 60 min), rat intestinal permeability (>3 times), biochemical and pharmacodynamic studies conferred the best to freeze dried (ratio; 1:2) and kneading (ratio; 1:2) complexes.

Keywords: COMPLEXATION; EPILEPSY; INTESTINAL PERMEABILITY; SHILAJIT; SOLUBILITY

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/sam.2011.1149

Publication date: April 1, 2011

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  • Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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