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Preparation and Orthopaedic Applications of Nanoparticle-Modified Biocompatible Surfaces

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Orthopaedic implants suffer from a multitude of undesirable effects which may cause them to fail prematurely, including but not exclusive to poor osseointegration, bacterial infection, aseptic loosening and osteolysis. As the need for implants increases, so does the need to strategically modify these surfaces to combat these undesirable effects. By gaining control of host and material activity at the bone-implant interface, many of these problems can be addressed. Furthermore, taking advantage of nanoparticle functionality opens a vast new area of study, where implant functionalization and bone structure interact on the same scale. By reviewing recent studies, the efficacy of nanoparticle-based implant modifications in different systems is discussed. This review provides an overview of nanoparticle-functionalized implant preparation techniques and the effect of nanoparticle-functionalized surfaces on osseointegration, anti-bacterial, and anti-cancer applications. We believe that understanding current preparation techniques of nanoparticle-functionalized implant surfaces and their effects will help in the development of novel materials for orthopaedic applications.
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Keywords: BACTERIA; CANCER; IMPLANTS; NANOMATERIALS; NANOPARTICLES; NANOTECHNOLOGY; ORTHOPAEDIC; OSSEOINTEGRATION; OSTEOBLASTS

Document Type: Review Article

Publication date: 01 February 2013

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  • Reviews in Nanoscience and Nanotechnology (RNN) is a multidisciplinary peer-reviewed journal covering fundamental and applied research in all disciplines of science, engineering and medicine. RNN publishes comprehensive reviews articles on all aspects of nanoscale science and technology dealing with materials synthesis, nanochemistry, processing, nanofabrication, nanoprobes, spectroscopy, properties, fullerenes, nanocomposites, theoretical and computational nanotechnology, nanophysics, nanoengineering, nanoelectronics, nano-optics, nano-mechanics, nanomagnetics, nanodevices, biological systems, nanobiotechnology, nanomedicine, drug delivery, nanotoxicology.
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