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Nanoparticle-Based Positron Emission Tomography and Single Photon Emission Computed Tomography Imaging of Cancer

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Nanoparticles (NPs) have been extensively investigated for cancer diagnosis and treatment by serving as either the carriers of small molecular agents or functional nanoentities towards the ultimate goal of nanomedicine. Such endeavors have been facilitated by combining with noninvasive molecular imaging techniques, especially positron emission tomography (PET) and single photon emission computed tomography (SPECT), because of their high sensitivity and capability of imaging quantification. To introduce the oncologic application of NP-based PET and SPECT imaging, this review provides the fundamental knowledge of PET and SPECT imaging for nanomedicine scientists to understand what to expect from these imaging techniques. Following an introduction to the general concepts of constructing NPs for molecular cancer imaging, recent advances in NP-based cancer research using PET and SPECT are summarized including multimodality imaging and theranostic applications. Future directions and challenges in this promising field are also discussed.
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Document Type: Research Article

Publication date: 2012-03-01

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  • Reviews in Nanoscience and Nanotechnology (RNN) is a multidisciplinary peer-reviewed journal covering fundamental and applied research in all disciplines of science, engineering and medicine. RNN publishes comprehensive reviews articles on all aspects of nanoscale science and technology dealing with materials synthesis, nanochemistry, processing, nanofabrication, nanoprobes, spectroscopy, properties, fullerenes, nanocomposites, theoretical and computational nanotechnology, nanophysics, nanoengineering, nanoelectronics, nano-optics, nano-mechanics, nanomagnetics, nanodevices, biological systems, nanobiotechnology, nanomedicine, drug delivery, nanotoxicology.
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