Oral Insulin Delivery: Unveiling Patented Approaches
Abstract:Oral route is the most commonly used, economical and convenient route of delivering drugs because no special skill is required for administering medications. Insulin is generally not delivered orally because of its proteinaceous nature due to which it undergoes inactivation by the acids and proteases of the gastrointestinal tract resulting in negligible oral bioavailability. Newer strategies are being explored for overcoming the problems associated with oral delivery of insulin. These include the use of permeation enhancers, protease inhibitors, enteric coatings and polymer microsphere formulations. These strategies aim at making insulin absorbable and bioavailable following oral administration. This article reviews the challenges and recently patented approaches in an endeavor to overcome the limitations associated with oral insulin delivery.
Document Type: Review Article
Publication date: December 1, 2012
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