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Cell Growth in a Porous Microcellular Structure: Influence of Surface Modification and Nanostructures

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This study investigates the growth, morphology and cell viability of bone cells (osteoblasts) inside microcellular graphitic foam having an interconnected porosity. This type of substrate can be useful as a scaffolding material for tissue growth, but has not been adequately investigated. The influence of various surface treatments was studied: an inorganic hydrophilic coating (silica), an organic coating (collagen), and grafting of carbon nanotubes (CNT) have been reported. It is seen that all foams have acceptable biocompatibility. Silica and collagen coatings tend to have more cell growth along pore walls but do not have any significant influence on overall nuclear density or cell viability. On the other hand, nanotube attachment results in simultaneous increase of cell proliferation, density and viability. These results indicate that attaching carbon nanotubes on surfaces of future implants may provide a hierarchical nanostructure with increased biocompatible surface area for improved cell attachment.
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Keywords: BIOCOMPATIBILITY; NANOTUBE ATTACHMENT; POROUS CARBON; SURFACE COATINGS; TISSUE ENGINEERING

Document Type: Short Communication

Publication date: 2011-02-01

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  • Nanoscience and Nanotechnology Letters (NNL) is a multidisciplinary peer-reviewed journal consolidating nanoscale research activities in all disciplines of science, engineering and medicine into a single and unique reference source. NNL provides the means for scientists, engineers, medical experts and technocrats to publish original short research articles as communications/letters of important new scientific and technological findings, encompassing the fundamental and applied research in all disciplines of the physical sciences, engineering and medicine.
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