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X-Ray Imaging Technique Using Colloid Solution of AgI/Silica/Poly(ethylene glycol) Nanoparticles

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This work describes X-ray imaging of mouse by using colloid solution of silica-coated AgI (AgI/SiO2 nanoparticles surface-modified with poly(ethylene glycol) (PEG) (AgI/SiO2/PEG). A colloid solution of AgI nanoparticles was prepared by mixing silver perchlorate and potassium iodide. AgI/SiO2 nanoparticles were fabricated by a sol–gel method using NaOH, H2O, and tetraethylorthosilicate in ethanol in the presence of AgI nanoparticles surface-modified with 3-mercaptopropyltrimethoxysilane. Surface-modification of the AgI/SiO2 particles with PEG, or PEGylation of the particle surface, was performed by using (3-aminopropyl)trimethoxysilane and poly(oxy-1,2-ethanediyl), α-methyl-ω-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyloxy] for the AgI/SiO2 particles. A computed tomography value of the AgI/SiO2/PEG colloid solution with an iodine concentration of 0.1 M was as high as 1328.1 HU, which was higher that a commercial X-ray contrast agent with the same iodine concentration. Internal organs such as liver, spleen, kidney and heart in a mouse could be imaged by injecting the concentrated colloid solution into it.
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Keywords: AGI; CORE–SHELL; NANOPARTICLE; POLY(ETHYLENE GLYCOL); SILICA; X-RAY CONTRAST AGENT

Document Type: Research Article

Publication date: 01 August 2012

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