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Free Content The Molecular Basis for Ca2 + Signalling by NAADP: Two-Pore Channels in a Complex?

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Abstract:

NAADP is a potent Ca2+ mobilizing messenger in a variety of cells but its molecular mechanism of action is incompletely understood. Accumulating evidence indicates that the poorly characterized two-pore channels (TPCs) in animals are NAADP sensitive Ca2+-permeable channels. TPCs localize to the endo-lysosomal system but are functionally coupled to the better characterized endoplasmic reticulum Ca2+ channels to generate physiologically relevant complex Ca2+ signals. Whether TPCs directly bind NAADP is not clear. Here we discuss the idea based on recent studies that TPCs are the pore-forming subunits of a protein complex that includes tightly associated, low molecular weight NAADP-binding proteins.

Keywords: CA2+ SIGNALING; ENDOSOMES; LYSOSOMES; NAADP; PHOTOAFFINITY LABELLING; TWO-PORE CHANNELS

Document Type: Review Article

DOI: http://dx.doi.org/10.1166/msr.2012.1003

Publication date: June 1, 2012

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  • The MESSENGER is an international peer-reviewed journal, focused on all aspects of messenger-signaling. The MESSENGER is devoted to all aspects of messenger- signaling, from the upstream activation of the receptors of the first messengers to the downstream signaling cascades. Undoubtedly, more novel second messengers will be discovered, expanding the scope of the journal appropriately. The MESSENGER publishes review articles, full research articles and short communications of important new scientific findings on all research aspects of messengers.
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