Home >> Journal of Scanning Probe Microscopy, Volume 4, Number 1

Free Content Statistical Analysis of Scanning Tunneling Microscopy Images of 'Striped' Mixed Monolayer Protected Gold Nanoparticles

Authors: Hu, Ying; Wunsch, Benjamin H.; Sahni, Sahil; Stellacci, Francesco

Source: Journal of Scanning Probe Microscopy, Volume 4, Number 1, June 2009 , pp. 24-35(12)

Publisher: American Scientific Publishers

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Abstract:

Recent studies based on scanning tunneling microscopy (STM) have shown that when gold nanoparticles are coated with binary mixtures of ligand molecules ribbon-like domains of alternating composition spontaneously form in the particles ligand shell. The presence of these domains has been linked to many surface properties, such as protein nonspecific adsorption, cell membrane permeation, or solubility. Here we present a detailed report on the methods and procedures used to acquire and analyze STM images of these ligand coated nanoparticles. We develop a novel statistical approach to analyze the images and differentiate them from images generated by feedback loop artifact. We conclude with a discussion of the potentials and problems of this technique.
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  • Scanning probe microscopy (SPM) typically covers atomic force microscopy (AFM), scanning tunneling microscopy (STM), near-field scanning optical microscopy (NSOM, or SNOM) and related technologies. Since its invention in early 1980s, SPM has now been regarded as one of the major driving forces for the rapid development of nanoscience and nanotechnology, and the tool of choice in many areas of research. Journal of Scanning Probe Microscopy (JSPM) provides a forum for rapid dissemination of important developments in SPM technology. JSPM offers scientists, engineers and developers timely, peer-reviewed research on SPM science and technology of the highest quality. JSPM publishes original rapid communications, full research papers and timely state-of-the-art reviews (with author's photo and biography) encompassing the fundamental and applied research on SPM in all fields of science, engineering, and medicine.
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