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Neural Regenerative Medicine and Detection Strategies for Neurochemistry

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Just very recently Canadian scientists presented to the world a bioelectronic device capable to offer to people with spinal cord injuries and stroke the possibility to regain feeling of movement and lost motor skills. The system uses compatible electronic pulses to stimulate paralyzed hands and arms and an accurate feedback to analyze the regenerative progress in time. The technology is considered a major advance, the first of its kind anywhere in the world. The inventors have called it, very properly, "Rejoice." The goal of regenerative medicine is to bring back joy and hope in the life of the people afflicted with accidents and disease by restoring their severely limited or non-existing abilities. In order to be effective, such a compassionate endeavour must be build on a profound understanding of the human biology both from a molecular and a holistic perspective, based on an integrated, interdisciplinary and coherent knowledge of the latest advances in nano- and microtechnologies, bioelectronics, bioenergetics, biophysics, biochemistry, neurology, chemistry, engineering and other correlated sciences. Even existing treatments (of degenerative neurological diseases for example) need to be refined, adapted and personalized in order to minimize the side-effects of pharmacological drugs and to overcome the problems related to the strong individual response of the patients. The latest developments in stem-cell research may just be the first step in implementing real personalized strategies in medicine. This paper is a review of the progress made in regenerative medicine, exploring different facets of this complex domain, from biocompatibility, brain prostheses, retinal implants to interfacing neurons with biosensing devices, detection methodologies and analytical perspectives. A special focus is concentrated on molecular level approaches, from microelectronic arrays of transistors and microelectrodes to optical methods of interrogations and non-invasive vibrational acoustic and electromagnetic fields measuring quantum level properties. From such explorations, of both quantum and macroscopic features of neuron cells, an authentic understanding of this mysterious wonder which is the human brain can emerge.
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Document Type: Research Article

Publication date: 2009-12-01

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  • Recent advances in nanomaterials indicates that the central nervous system (CNS) is susceptible to nanoparticle induced alterations leading to functional or structural alterations. This knowledge is currently disseminated in vast array of journals dealing with broad subject areas related to pharmacology, toxicology, neuroscience or nanosciences. Thus, there is an urgent need to collect all these diverse information related to nanoscience and brain function in one place using Journal of Nanoneuroscience for the benefit of the scientific community, researchers, health planners, health care providers, policy makers, environmentalists, biologists, chemists, and physicist in this emerging area of medical science.
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