Carbon-Based Nanoparticles and Innate Immune Responses in the Brain
Abstract:The rapid progression of nanotechnology has opened limitless possibilities for the use of highly organized nanosized particles as medical tools and devices. Although the field is rapidly developing, not much is known about the potential toxicity of various carbon-based nanomaterials. Chronic immune responses to such compounds may pose a potential harm to humans, especially if the particles are not biodegradable or otherwise removable. In the brain, where immunological processes involved in degradation of foreign substances are limited, the removal of nanoparticles may be complicated and slow. In this brief review the possible adverse central nervous system (CNS) effects of carbon-based nanomaterial, with an emphasis on potential neuroinflammatory responses, will be discussed.
Document Type: Review Article
Publication date: December 1, 2009
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- Recent advances in nanomaterials indicates that the central nervous system (CNS) is susceptible to nanoparticle induced alterations leading to functional or structural alterations. This knowledge is currently disseminated in vast array of journals dealing with broad subject areas related to pharmacology, toxicology, neuroscience or nanosciences. Thus, there is an urgent need to collect all these diverse information related to nanoscience and brain function in one place using Journal of Nanoneuroscience for the benefit of the scientific community, researchers, health planners, health care providers, policy makers, environmentalists, biologists, chemists, and physicist in this emerging area of medical science.
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