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An Improved Sum of Edge Clustering Coefficient Method for Essential Protein Identification

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It is an extremely important issue in drug design to identify essential protein and understand the minimal requirements for cellular life. In the present, it is still one of the major challenges to find essential protein with the rapid increase of available protein–protein interaction data. Sum of edge clustering coefficient (SoECC) has been proved effective than other centrality measures in yeast protein–protein interaction (PPI) network. This paper presents a novel essential protein identification method CCIS based on improved SoECC (ISoECC) method and connected components. In the process, there are other two variations, change number of connected components (CNCC) and change number of maximum connected components (CNMCC) acting as a criterion to score each node. Experimental results show that although the number of essential proteins found by the proposed method does not exceeds that found by SoECC, the proposed method has better generalization ability in the whole network and its performance is much better than other measures, such as DC, BC, CC, SC, EC, IC, BN, RL, LI, LR, NC, MC and SoECC.
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Keywords: CCIS; ESSENTIAL PROTEIN; ISOECC; PPI NETWORK

Document Type: Research Article

Publication date: 01 August 2013

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  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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