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The Combination Effect of Poly(lactic-co-glycolic acid) Coated Iron Oxide Nanoparticles as 5-Fluorouracil Carrier and X-Ray on the Level of DNA Damages in the DU 145 Human Prostate Carcinoma Cell Line

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Abstract:

The purpose of this study was to investigate the effect of magnetic nanoparticles as a carrier of 5-fluorouracil and X-ray on the level of DNA damages in monolayer model of DU145 prostate carcinoma cell lines. Therefore, DU145 cells were cultured as monolayer and treated with different concentrations of 5-FU/or nanoparticles as 5-FU carriers for 24 hours and 2 Gy X-ray (6 MV). After treatment, the induced DNA damages were examined using alkaline comet assay. Our results showed that DNA damages increased as along with the increase of the concentration of free 5FU and PLGA coated iron oxide nanoparticles as a carrier of 5-fluorouracil in combination with X-ray. However the extend of induction of DNA damages from 5-FU in polymeric coated iron oxide nanoparticles in combination with 2 Gy of megavoltage X-ray was significantly more than free 5-Fu. Since drug loaded nanoparticles could deliver 5-Fu more efficient into the cells, magnetic nanoparticles are stable and effective drug delivery vehicles for 5-FU.

Keywords: 5-FLUOROURACIL; DAMAGES; DNA; PLGA COATED IRON OXIDE NANOPARTICLES; PROSTATE CANCER

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbns.2012.1063

Publication date: June 1, 2012

More about this publication?
  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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