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Rifampicin–Loaded Poly(lactic-co-glycolic) Acid Microspheres: Synthesis, Characterization, Delivery and Their Antimicrobial Studies

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Abstract:

A series of biodegradable poly (lactic-co-glycolic) acid copolymer have been synthesized by direct melt poly condensation. The synthesized copolymers have been characterized by Infrared and Nuclear Magnetic Resonance Spectroscopy. Rifampicin loaded Poly (lactic-co-glycolic) acid microparticles have been prepared by multiple emulsion solvent evaporation technique. The Rifacmpicin loaded Poly (lactic-co-glycolic) acid microparticles have been characterized by Scanning Electron Microscopy and Particle Size Analyzer. Microparticles were spherical in shape with a relatively monodisperesed size distribution. The drug loading efficiency, drug content and in vitro release behavior of the Rifampicin loaded Poly (lactic-co-glycolic) acid microparticles have been determined by Ultraviolet-visible spectroscopy. The drug releasing effect of Rifampicin loaded Poly (lactic-co-glycolic) acid microspheres was examined by conducting the antibacterial test for Staphylococcus aureus and Escherichia coli systems, the results shows the Rifampicin loaded Poly(lacticco-glycolic) acid microspheres effectively inhibit the bacterial growth within 48 h duration.

Keywords: ANTIMICROBIAL ACTIVITY; MICROSPHERES; POLY LACTIC-CO-GLYCOLIC ACID (PLGA); RIFAMPICIN

Document Type: Research Article

DOI: http://dx.doi.org/10.1166/jbns.2011.1043

Publication date: June 1, 2011

More about this publication?
  • Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
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