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Cellular Oxidative Stress Response to Graphene Oxide Films Functionalized by NH3 Plasma

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Functionalization of graphene oxide (GO) films was performed for the enhancement of bioaffinity by NH3 plasma treatment. Our results demonstrated that the damage free treatments caused a significant change in the surface charge states from negatively charged states with oxygen containing groups on the pristine GO to positively charged states with amine groups on the functionalized GO (f-GO) films. The effects of the conversion of the surface charge states of GO on bioaffinity and biocompatibility were investigated through studies of the reactive oxygen species (ROS) generation mitochondrial morphology and cell proliferation and viability during the growth of HeLa cells on GO and f-GO films. The proliferation and viability of HeLa cells on GO and f-GO films were enhanced compared to those of the control cells. Also the ROS generation on the f-GO (20s treatment) films compared to the other films was reduced. The different physicochemical properties of f-GO induced by plasma-chemical functionalization had a decisive influence on the ROS generation and the proliferation and viability of cells.
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Keywords: Cell Proliferation; Cell Viability; Graphene Oxide; NH3 Plasma Treatments; ROS Generation

Document Type: Research Article

Affiliations: 1: Da Vinci College of General Education, Institute of Innovative Functional Imaging, Chung-Ang University, Seoul 06974, Korea 2: Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University (SKKU), Suwon, Gyunggi-do 16419, Korea 3: School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, Gyunggi-do 16419, Korea

Publication date: 2017-11-01

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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